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Acne vulgaris

MedGen UID:
95
Concept ID:
C0001144
Disease or Syndrome
Synonym: Acne Vulgaris
SNOMED CT: Acne vulgaris (88616000); Common acne (88616000)

Definition

An inflammatory process of the sebaceous glands which is characterized by comedones, nodules, papules and/or pustules on the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcne vulgaris

Professional guidelines

PubMed

Reynolds RV, Yeung H, Cheng CE, Cook-Bolden F, Desai SR, Druby KM, Freeman EE, Keri JE, Stein Gold LF, Tan JKL, Tollefson MM, Weiss JS, Wu PA, Zaenglein AL, Han JM, Barbieri JS
J Am Acad Dermatol 2024 May;90(5):1006.e1-1006.e30. Epub 2024 Jan 30 doi: 10.1016/j.jaad.2023.12.017. PMID: 38300170
Eichenfield DZ, Sprague J, Eichenfield LF
JAMA 2021 Nov 23;326(20):2055-2067. doi: 10.1001/jama.2021.17633. PMID: 34812859
Zaenglein AL, Pathy AL, Schlosser BJ, Alikhan A, Baldwin HE, Berson DS, Bowe WP, Graber EM, Harper JC, Kang S, Keri JE, Leyden JJ, Reynolds RV, Silverberg NB, Stein Gold LF, Tollefson MM, Weiss JS, Dolan NC, Sagan AA, Stern M, Boyer KM, Bhushan R
J Am Acad Dermatol 2016 May;74(5):945-73.e33. Epub 2016 Feb 17 doi: 10.1016/j.jaad.2015.12.037. PMID: 26897386

Recent clinical studies

Etiology

Kutlu Ö, Karadağ AS, Wollina U
An Bras Dermatol 2023 Jan-Feb;98(1):75-83. Epub 2022 Oct 14 doi: 10.1016/j.abd.2022.01.006. PMID: 36253244Free PMC Article
Genovese G, Moltrasio C, Garcovich S, Marzano AV
G Ital Dermatol Venereol 2020 Oct;155(5):542-550. Epub 2020 Jul 2 doi: 10.23736/S0392-0488.20.06629-8. PMID: 32618443
Dréno B, Pécastaings S, Corvec S, Veraldi S, Khammari A, Roques C
J Eur Acad Dermatol Venereol 2018 Jun;32 Suppl 2:5-14. doi: 10.1111/jdv.15043. PMID: 29894579
Moradi Tuchayi S, Makrantonaki E, Ganceviciene R, Dessinioti C, Feldman SR, Zouboulis CC
Nat Rev Dis Primers 2015 Sep 17;1:15029. doi: 10.1038/nrdp.2015.29. PMID: 27189872
Titus S, Hodge J
Am Fam Physician 2012 Oct 15;86(8):734-40. PMID: 23062156

Diagnosis

Jennings T, Duffy R, McLarney M, Renzi M, Heymann WR, Decker A, Lawrence N
J Am Acad Dermatol 2024 Jun;90(6):1123-1134. Epub 2022 Jul 2 doi: 10.1016/j.jaad.2022.04.021. PMID: 35792196
Mohsin N, Hernandez LE, Martin MR, Does AV, Nouri K
Dermatol Ther 2022 Sep;35(9):e15719. Epub 2022 Jul 26 doi: 10.1111/dth.15719. PMID: 35841269
Yee BE, Richards P, Sui JY, Marsch AF
Dermatol Ther 2020 Nov;33(6):e14252. Epub 2020 Sep 15 doi: 10.1111/dth.14252. PMID: 32860489
Fox L, Csongradi C, Aucamp M, du Plessis J, Gerber M
Molecules 2016 Aug 13;21(8) doi: 10.3390/molecules21081063. PMID: 27529209Free PMC Article
Titus S, Hodge J
Am Fam Physician 2012 Oct 15;86(8):734-40. PMID: 23062156

Therapy

Rosmarin D, Passeron T, Pandya AG, Grimes P, Harris JE, Desai SR, Lebwohl M, Ruer-Mulard M, Seneschal J, Wolkerstorfer A, Kornacki D, Sun K, Butler K, Ezzedine K; TRuE-V Study Group
N Engl J Med 2022 Oct 20;387(16):1445-1455. doi: 10.1056/NEJMoa2118828. PMID: 36260792
Li MK, Liu C, Hsu JTS
Am J Clin Dermatol 2021 Nov;22(6):785-800. Epub 2021 Jul 21 doi: 10.1007/s40257-021-00624-5. PMID: 34287769
Schoenberg E, O'Connor M, Wang JV, Yang S, Saedi N
J Cosmet Dermatol 2020 Jan;19(1):112-114. Epub 2019 May 9 doi: 10.1111/jocd.12988. PMID: 31070298
Kolli SS, Pecone D, Pona A, Cline A, Feldman SR
Am J Clin Dermatol 2019 Jun;20(3):345-365. doi: 10.1007/s40257-019-00423-z. PMID: 30674002
Hou A, Cohen B, Haimovic A, Elbuluk N
Dermatol Surg 2017 Mar;43(3):321-339. doi: 10.1097/DSS.0000000000000924. PMID: 27755171

Prognosis

Dessinioti C, Katsambas A
Yale J Biol Med 2022 Dec;95(4):429-443. Epub 2022 Dec 22 PMID: 36568833Free PMC Article
Gebauer K
Aust Fam Physician 2017 Dec;46(12):892-895. PMID: 29464224
Zaenglein AL, Pathy AL, Schlosser BJ, Alikhan A, Baldwin HE, Berson DS, Bowe WP, Graber EM, Harper JC, Kang S, Keri JE, Leyden JJ, Reynolds RV, Silverberg NB, Stein Gold LF, Tollefson MM, Weiss JS, Dolan NC, Sagan AA, Stern M, Boyer KM, Bhushan R
J Am Acad Dermatol 2016 May;74(5):945-73.e33. Epub 2016 Feb 17 doi: 10.1016/j.jaad.2015.12.037. PMID: 26897386
Pezza M, Carlomagno V, Casucci G
G Ital Dermatol Venereol 2015 Dec;150(6):649-53. Epub 2014 Jul 31 PMID: 25077885
Williams HC, Dellavalle RP, Garner S
Lancet 2012 Jan 28;379(9813):361-72. Epub 2011 Aug 29 doi: 10.1016/S0140-6736(11)60321-8. PMID: 21880356

Clinical prediction guides

Guertler A, Volsky A, Eijkenboom Q, Fiedler T, French LE, Reinholz M
Nutrients 2023 Oct 17;15(20) doi: 10.3390/nu15204405. PMID: 37892480Free PMC Article
Santer M, Lawrence M, Renz S, Eminton Z, Stuart B, Sach TH, Pyne S, Ridd MJ, Francis N, Soulsby I, Thomas K, Permyakova N, Little P, Muller I, Nuttall J, Griffiths G, Thomas KS, Layton AM; SAFA trial investigators
BMJ 2023 May 16;381:e074349. doi: 10.1136/bmj-2022-074349. PMID: 37192767Free PMC Article
Chen H, Zhang TC, Yin XL, Man JY, Yang XR, Lu M
Br J Dermatol 2022 Apr;186(4):673-683. Epub 2022 Jan 20 doi: 10.1111/bjd.20882. PMID: 34758111
Aktaş Karabay E, Aksu Çerman A
An Bras Dermatol 2020 Mar-Apr;95(2):187-193. Epub 2020 Feb 12 doi: 10.1016/j.abd.2019.08.023. PMID: 32113677Free PMC Article
Huang YC, Cheng YC
J Am Acad Dermatol 2017 Jun;76(6):1068-1076.e9. Epub 2017 Mar 11 doi: 10.1016/j.jaad.2016.12.028. PMID: 28291553

Recent systematic reviews

Reynolds RV, Yeung H, Cheng CE, Cook-Bolden F, Desai SR, Druby KM, Freeman EE, Keri JE, Stein Gold LF, Tan JKL, Tollefson MM, Weiss JS, Wu PA, Zaenglein AL, Han JM, Barbieri JS
J Am Acad Dermatol 2024 May;90(5):1006.e1-1006.e30. Epub 2024 Jan 30 doi: 10.1016/j.jaad.2023.12.017. PMID: 38300170
Mavranezouli I, Daly CH, Welton NJ, Deshpande S, Berg L, Bromham N, Arnold S, Phillippo DM, Wilcock J, Xu J, Ravenscroft JC, Wood D, Rafiq M, Fou L, Dworzynski K, Healy E
Br J Dermatol 2022 Nov;187(5):639-649. Epub 2022 Aug 22 doi: 10.1111/bjd.21739. PMID: 35789996Free PMC Article
Yee BE, Richards P, Sui JY, Marsch AF
Dermatol Ther 2020 Nov;33(6):e14252. Epub 2020 Sep 15 doi: 10.1111/dth.14252. PMID: 32860489
Heng AHS, Chew FT
Sci Rep 2020 Apr 1;10(1):5754. doi: 10.1038/s41598-020-62715-3. PMID: 32238884Free PMC Article
Fiedler F, Stangl GI, Fiedler E, Taube KM
Acta Derm Venereol 2017 Jan 4;97(1):7-9. doi: 10.2340/00015555-2450. PMID: 27136757

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